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currentsinbiology:

Why do we sleep? To clean our brains, say US scientists (The Guardian)

Scientists in the US claim to have a new explanation for why we sleep: in the hours spent slumbering, a rubbish disposal service swings into action that cleans up waste in the brain.

Through a series of experiments on mice, the researchers showed that during sleep, cerebral spinal fluid is pumped around the brain, and flushes out waste products like a biological dishwasher.

The process helps to remove the molecular detritus that brain cells churn out as part of their natural activity, along with toxic proteins that can lead to dementia when they build up in the brain, the researchers say.

Maiken Nedergaard, who led the study at the University of Rochester, said the discovery might explain why sleep is crucial for all living organisms. “I think we have discovered why we sleep,” Nedergaard said. “We sleep to clean our brains.”

Writing in the journal Science, Nedergaard describes how brain cells in mice shrank when they slept, making the space between them on average 60% greater. This made the cerebral spinal fluid in the animals’ brains flow ten times faster than when the mice were awake.